Wednesday, October 31, 2012

Variation phénotypique cours

Plasticité phénotypique

= babies born above 3000m are smaller. Have blood richer in red blood cells.

Too much sun and light skin:
Flavines carotenoids tocopherol folates sont sensible à la photodegradation

Folates - mineralisation osseuse et maturation neurocérébrale (Neural Tube Defects)

Also leads to male infertility

Vit D agit comme hormone et régule l'absorption du Ca. Not enough Vit D = Rickets

Map of skin pigmentation indicates the oldness of African habitation and the newness of American habitation. Ex: there wasn't enough time for amazonians to adapt to high UV levels as the Congolese have.

allele néanderthal pour la peau claire n'est pas présent chez l'homme.

Sexual selection, how does that work?
And I don't wanna talk to a sci-en-tist.
Y'all be lyin' and getten me pissed.

Why do most animals lose the ability to digest milk at a certain age? To induce weaning?

Fairly rare for humans to digest milk, mutation allows digestion. Arrived with the domestication of bovids.


It turns out that gene regulators determine how much Lactase is produced; how much mRNA codes for this milk digestor. Usually it reins in lactase production at a certain age. A mutation stopped this action.

Gluten intolerance is similar. Before the neolithic nobody ate wheat.

NOVEL ENVIRONMENT. Milk, gluten, alcohol... but alcohol was probably made much earlier. Hunter gatherers were probably wise to the alcohol level in rotten fruit, and encouraged this.

Diminuation de taille = effet de dérive augmente

L'avenir
plus en plus de migration
moins en moins de selection
la variabilité phenotypique va diminuer.

Selection sexuelle va toujours agir... new technology allows individuals to reproduce artificially with "attractive" people at a high rate.

reproduction assisté = frequences allèliques ne sont pas déterminées par l'union au hasard des gamètes! Surreprésentation du génotype de certains donneurs de sperme.

Ethique....

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